As iron continues to build up in the body, complications happen more often.

Transfused sickle cell disease patients with iron overload were
compared to those without iron overload in a review of clinical trials in 2018 which showed that sickle cell patients with iron overload had
higher rates of:

Mortality Stats 64%
(64% vs. 5%) 
Organ failure
Organ failure
(71% vs. 19%)
Pain episodes
Pain episodes
(64% vs. 38%)

N=35; defined as serum ferritin levels >1500 ng/mL and transferrin saturation >50%.


Monitor renal function

Kidney complications are common in the general population of patients with sickle cell disease. Ensure regular monitoring of both renal and hepatic function for transfused patients.

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